[Return Code 451] sid: Ve9e1o0012Rj2se01 :: Sorry, I wasn’t able to establish an SMTP connection. I’m not going to try again; this message has been in the queue too long.

Typically, 451 errors are due to the receiving server rejecting your email. This can happen for a number of reasons but most likely is due to the recipients server being overloaded with messages. It can also mean that the recipients server has grey-listed the IP, and therefore delays the message until it can verify that the sending server is not trying to send spam. The receiving server may be offline as well.